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Why Settle for Less?

According to the Center for Disease, Control, & Prevention, obesity in the United states affects over 100.1 million people. It has been linked to the majority of chronic diseases and is the leading cause of heart disease, stroke, diabetes, and even death. Lastly, it has also been linked to an increased risk of certain types of cancer. Even a modest weight loss of 5% to 10% of your total body weight is likely to produce health benefits, such as improvements in mood, blood pressure, blood cholesterol, and blood sugars.

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Peptides: What is Semaglutide?

Semaglutide is a peptide that mimics the naturally occurring hormone called glucagon-like peptide (GLP-1.) GLP-1, secreted from nutrient responsive enteroendocrine cells or L cells of intestine, is a prominent incretin hormone responsible for glucoregulatory effect in the human body.

Semaglutide is a peptide that increases insulin secretion, lowers blood sugar levels, helps reduce your appetite, and cravings. Semaglutide offers adults with abnormal excess accumulation of body fat or a body mass index (BMI) greater than 30, a new beneficial treatment option to incorporate into a weight management program.

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HOT TIP from prosperIV:

It’s very hard to find the time to get a balanced meal in. If you want to give your meal plan a boost, try The prosperIV signature drip!

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How does it work?

GLP-1 plays an important role in digestion by delaying gastric emptying and suppresses appetite centers in the hypothalamus. GLP-1 plays a vital role in improving insulin resistance and production of VLDL (Very Low-Density Lipoprotein) via an intrinsic gut-liver signaling pathway.

Peptides are short chain amino acids connected with a peptide bond. Peptides promote weight loss by promoting food satiety and increasing muscle mass. The GLP-1 RA drug class is associated with multiple benefits; they have a well-documented safety profile, reduce body weight, improve blood pressure, lipid profile and other cardiovascular risk factors as well as glucose metabolism.

Since Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue, it is classified as a GLP-1 receptor agonist (GLP-1 RA). It has a 94% homology to human GLP-1 and a long half-life suitable for once-weekly dosing. They are available from prosperIV through weekly subcutaneous injections administered by one of our professional registered nurses by being a part of one of our Monthly club membership wellness programs.

The Peptide Wellness Program - Month One

Package includes: (monthly, non-refundable)

  • The prosperIV Peptide Wellness Program  - starts at $650.
  • (1) 30-45 minute Initial Zoom consultation with our Board Certified Nurse Practitioner, Medical Director prior to starting program
  • (1) 15 minute follow up Zoom or phone call visit before increasing dosage
  • (4)Access to HIPAA compliant patient portal for ongoing weekly support, etc.
  • (4) injections - 1x/week, at any location with a Professional Registered Nurse
  • (1) 1000ml Lactated Ringers IV Drip with a high dose Multivitamin* 
  • 15% off all other Vitamin drips & boosters
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*Our Exclusive Lactated Ringers IV Drip

Indicated as a daily multivitamin maintenance supplement for adults and children aged 11 and older. The IV Vitamin Infusion contributes to intake of necessary vitamins toward maintaining the body’s normal resistance and repair processes.

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What to expect:

Since semaglutide affects how your body perceives and digests food, it can cause gastrointestinal upset and several common symptoms when you first start using it. As your body adjusts, semaglutide should give you a feeling of fullness and satisfaction that makes it easier to reduce your caloric intake and enjoy significant weight loss.

Some of the common, expected symptoms are: Nausea, vomiting, stomach upset, diarrhea, tiredness, dizziness, and constipation may occur. Nausea usually lessens as you continue to use semaglutide and use natural interventions to combat these symptoms. If any of these effects lasts longer than 3 days or worsens, inform your provider, PCP, or pharmacist promptly.

In addition to taking Semaglutide injections, it is also essential that you maintain a healthy lifestyle for this treatment to be effective. This means some very imperative lifestyle changes. Eating nutritious meals that are plant-based, organic, and exercising 30 minutes (any activity), 3-4 times per week. 

Eating healthy foods that are called Macronutrients such as proteins (seafoods, animal meats, eggs, beans, or nuts, etc.), complex carbohydrates (fruits, vegetables, and whole grains, etc.), along with healthy fats, will help curb cravings.  Exercising burns off extra calories and helps keep your metabolism active so that you can continue losing weight even after you stop taking the injections.

Some people begin to see results within the first eight weeks, but most begin to see results within 12 weeks. Clinical trials have shown that study participants taking a weekly dose of semaglutide had an average reduction in body weight of 5-10 percent. Going slow is ideal in order to prevent the side effects that will occur if your body is losing weight too fast. 

*Patients should expect to commit for 3 months, each month is evaluated by the medical director before next steps are recommended.

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What is the clinical data that supports this?

Clinical Trials for Anti-obesity Effect of Semaglutide

Semaglutide has exhibited significant weight reducing property in various phase-3 SUSTAIN and PIONEER trials over dulaglutide and liraglutide. These results encouraged the researchers to carry out trials on weekly-once subcutaneous semaglutide for better management of obesity.

A cross over trial study on 30 obese subjects investigated the mechanism of semaglutide by studying energy intake, appetite sensation, gastric emptying, and postprandial glucose as well as triglyceride metabolism. Participants received weekly-once s.c. semaglutide (initially 0.25, then 0.5 and finally 1.0 mg with dose escalation) or placebo for 12-weeks, followed by a washout period of 5 to 7 weeks, and finally another 12-weeks treatment period. Semaglutide has shown about 24% drop in net calorie consumption with 5 kg weight reduction. Therefore, lower energy intake, enhanced satiation, less food craving, reduced body fat and weight loss are the plausible mechanism for the anorexic effect of semaglutide.

Semaglutide is a clinically approved drug for type 2 diabetes, obesity, and a clinical trial candidate for management of NASH, Parkinson’s and Alzheimer’s disease. Semaglutide is well tolerated and can be safely used in patients with renal, hepatic and CV diseases. Hepatoprotective and neuroprotective role of semaglutide in abating NASH and neurodegenerative diseases respectively has been proved in phase-2 trials and is still under study. It improves insulin resistance in the periphery as well as in the brain, reduces body weight, and reduces fat content in the liver by acting as an agonist on GLP-1 receptors. The efficacy of semaglutide in alleviating cardiac injury in COVID-19 patients with diabetes, obesity, hypertension and CV diseases is being studied. Based on drug repurposing strategy, researchers are trying their best to explore various therapeutic potentials of semaglutide. Clinical efficacy in different therapeutic fields proved semaglutide to be an indispensable treatment option for better management of “diabesity” and an emerging cynosure for management of NASH and neurodegenerative diseases.

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Recommended Boosts

You will love enhancing your vitamin drip infusions with a boost! These drip enhancers maximize results, add extra benefits to your IV, and can be personalized to your specific needs to help you feel even better. 

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